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Article

PAR2 (Protease-Activated Receptor 2) Deficiency Attenuates Atherosclerosis in Mice.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2018

Jones Shannon M, Mann Adrien, Conrad Kelsey, Saum Keith, Hall David E, McKinney Lisa M, Robbins Nathan, Thompson Joel, Peairs Abigail D, Camerer Eric, Rayner Katey J, Tranter Michael, Mackman Nigel, Owens A Phillip

Abstract excerpt

OBJECTIVE: PAR2 (protease-activated receptor 2)-dependent signaling results in augmented inflammation and has been implicated in the pathogenesis of several autoimmune conditions. The objective of this study was to determine the effect of PAR2 deficiency on the development of atherosclerosis. APPROACH AND RESULTS: PAR2 mRNA and protein expression is increased in human carotid artery and mouse aortic arch atheroma...

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Source

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Identifiers

PMID: 29599135
DOI: 10.1161/ATVBAHA.117.310082
PMCID: PMC6324171

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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