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Article

Divergent roles of matrix metalloproteinase 2 in pathogenesis of thoracic aortic aneurysm.

Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2015

Shen Mengcheng, Lee Jiwon, Basu Ratnadeep, Sakamuri Siva S V P, Wang Xiuhua, Fan Dong, Kassiri Zamaneh

Abstract excerpt

OBJECTIVE: Aortic aneurysm, focal dilation of the aorta, results from impaired integrity of aortic extracellular matrix (ECM). Matrix metalloproteinases (MMPs) are traditionally known as ECM-degrading enzymes. MMP2 has been associated with aneurysm in patients and in animal models. We investigated the role of MMP2 in thoracic aortic aneurysm using 2 models of aortic remodeling and aneurysm. APPROACH AND RESULTS:...

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Topics

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Share to Aorta, Thoracic
Share to Aortic Aneurysm, Thoracic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calcium Chloride

Share to Dilatation, Pathologic

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Share to Smad2 Protein

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Source

Identifiers

PMID: 25657308
DOI: 10.1161/ATVBAHA.114.305115

Genes

MMP2

Provenance

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