Article
Exomic analysis of myxoid liposarcomas, synovial sarcomas, and osteosarcomas.
Genes, chromosomes & cancer - 1 Jan 2014
Joseph Christine G, Hwang Heejung, Jiao Yuchen, Wood Laura D, Kinde Isaac, Wu Jian, Mandahl Nils, Luo Jinyong, Hruban Ralph H, Diaz Luis A, He Tong-Chuan, Vogelstein Bert, Kinzler Kenneth W, Mertens Fredrik, Papadopoulos Nickolas
Abstract excerpt
Bone and soft tissue sarcomas are a group of histologically heterogeneous and relatively uncommon tumors. To explore their genetic origins, we sequenced the exomes of 13 osteosarcomas, eight myxoid liposarcomas (MLPS), and seven synovial sarcomas (SYN). These tumors had few genetic alterations (median of 10.8). Nevertheless, clear examples of driver gene mutations were observed, including canonical mutations in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.