Article
Genomic landscape of liposarcoma.
Oncotarget - 15 Dec 2015
Kanojia Deepika, Nagata Yasunobu, Garg Manoj, Lee Dhong Hyun, Sato Aiko, Yoshida Kenichi, Sato Yusuke, Sanada Masashi, Mayakonda Anand, Bartenhagen Christoph, Klein Hans-Ulrich, Doan Ngan B, Said Jonathan W, Mohith S, Gunasekar Swetha, Shiraishi Yuichi, Chiba Kenichi, Tanaka Hiroko, Miyano Satoru, Myklebost Ola, Yang Henry, Dugas Martin, Meza-Zepeda Leonardo A, Silberman Allan W, Forscher Charles, Tyner Jeffrey W, Ogawa Seishi, Koeffler H Phillip
Abstract excerpt
Liposarcoma (LPS) is the most common type of soft tissue sarcoma accounting for 20% of all adult sarcomas. Due to absence of clinically effective treatment options in inoperable situations and resistance to chemotherapeutics, a critical need exists to identify novel therapeutic targets. We analyzed LPS genomic landscape using SNP arrays, whole exome sequencing and targeted exome sequencing to uncover the genomic...
Topics
- Animals
- DNA Mutational Analysis
- Flow Cytometry
- Gene Knockdown Techniques
- Heterografts
- High-Throughput Nucleotide Sequencing
- Humans
- Liposarcoma