Article
Integrated genomic and transcriptomic analysis revealed mutation patterns of de-differentiated liposarcoma and leiomyosarcoma.
BMC cancer - 28 Oct 2020
Liu Wenshuai, Tong Hanxing, Zhang Chenlu, Zhuang Rongyuan, Guo He, Lv Chentao, Yang Hua, Lin Qiaowei, Guo Xi, Wang Zhiming, Wang Yan, Shen Feng, Wang Shengzhou, Dai Chun, Wang Guan, Liu Jun, Lu Weiqi, Zhang Yong, Zhou Yuhong
Abstract excerpt
BACKGROUND: Treating patients with advanced sarcomas is challenging due to great histologic diversity among its subtypes. Leiomyosarcoma (LMS) and de-differentiated liposarcoma (DDLPS) are two common and aggressive subtypes of soft tissue sarcoma (STS). They differ significantly in histology and clinical behaviors. However, the molecular driving force behind the difference is unclear. METHODS: We collected 20 LMS...
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