Article
The Landscape of Alterations from 1407 Ultra-Rare Sarcomas from the AACR GENIE Database: Clinical Implications.
Clinical cancer research : an official journal of the American Association for Cancer Research - 14 Nov 2023
Denu Ryan A, Moyers Justin T, Gouda Mohamed A, Conley Anthony P, Lazar Alexander J, Subbiah Vivek
Abstract excerpt
PURPOSE: Ultra-rare sarcomas (URS) comprise a group of orphan diseases with an incidence of ≤1/1,000,000 people per year. We aimed to assess clinically actionable genomic alterations in URS. EXPERIMENTAL DESIGN: Data were extracted from the GENIE database using cBioPortal. OncoKB was used to assess for clinical actionability of mutations. Tumor mutational burden (TMB) was inferred from clinical sequencing data....
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