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Article

Integrated genetic and epigenetic analysis of myxofibrosarcoma.

Nature communications - 17 Jul 2018

Ogura Koichi, Hosoda Fumie, Arai Yasuhito, Nakamura Hiromi, Hama Natsuko, Totoki Yasushi, Yoshida Akihiko, Nagai Momoko, Kato Mamoru, Arakawa Erika, Mukai Wakako, Rokutan Hirofumi, Kawai Akira, Tanaka Sakae, Shibata Tatsuhiro

Abstract excerpt

Myxofibrosarcoma (MFS) is a common adult soft tissue sarcoma characterized by an infiltrative growth pattern and a high local recurrence rate. Here we report the genetic and epigenetic landscape of MFS based on the results of whole-exome sequencing (N = 41), RNA sequencing (N = 29), and methylation analysis (N = 41), using 41 MFSs as a discovery set, and subsequent targeted sequencing of 140 genes in the entire...

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Identifiers

PMID: 30018380
DOI: 10.1038/s41467-018-03891-9
PMCID: PMC6050269

Genes

ATRX
BRAF
JAK1
NTRK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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