Integrated exome and RNA sequencing of dedifferentiated liposarcoma.

doi:10.1038/s41467-019-13286-z

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Article

Integrated exome and RNA sequencing of dedifferentiated liposarcoma.

Nature communications - 12 Dec 2019

Hirata Makoto, Asano Naofumi, Katayama Kotoe, Yoshida Akihiko, Tsuda Yusuke, Sekimizu Masaya, Mitani Sachiyo, Kobayashi Eisuke, Komiyama Motokiyo, Fujimoto Hiroyuki, Goto Takahiro, Iwamoto Yukihide, Naka Norifumi, Iwata Shintaro, Nishida Yoshihiro, Hiruma Toru, Hiraga Hiroaki, Kawano Hirotaka, Motoi Toru, Oda Yoshinao, Matsubara Daisuke, Fujita Masashi, Shibata Tatsuhiro, Nakagawa Hidewaki, Nakayama Robert, Kondo Tadashi, Imoto Seiya, Miyano Satoru, Kawai Akira, Yamaguchi Rui, Ichikawa Hitoshi, Matsuda Koichi

Abstract excerpt

The genomic characteristics of dedifferentiated liposarcoma (DDLPS) that are associated with clinical features remain to be identified. Here, we conduct integrated whole exome and RNA sequencing analysis in 115 DDLPS tumors and perform comparative genomic analysis of well-differentiated and dedifferentiated components from eight DDLPS samples. Several somatic copy-number alterations (SCNAs), including the gain of...

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Identifiers

PMID: 31831742
DOI: 10.1038/s41467-019-13286-z
PMCID: PMC6908635

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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