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Article

Molecular Characterization of Soft Tissue Sarcomas Using RNA-Based Next-Generation Sequencing.

International journal of molecular sciences - 16 Mar 2026

Serban Bogdan, Cursaru Adrian, Iordache Sergiu, Cretu Bogdan, Nica Mihai, Iacobescu Georgian, Popa Mihnea, Radu Eugen, Cirnu Madalina, Cirstoiu Catalin

Abstract excerpt

Soft tissue sarcomas are rare malignant mesenchymal tumors for which accurate diagnosis, prognostic stratification, and therapeutic decision-making remain challenging. Although histopathology and immunohistochemistry are essential diagnostic tools, they frequently fail to capture the molecular complexity underlying tumor aggressiveness and treatment resistance. In this study, we evaluated the utility of RNA-based...

Topics

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Aged
Biomarkers, Tumor
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
High-Throughput Nucleotide Sequencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sequence Analysis, RNA

Source

Open in PubMed Open full text

Identifiers

PMID: 41898560
DOI: 10.3390/ijms27062699
PMCID: PMC13026488

Genes

BUB1B
COL11A1
HOXD13
MELK
MKI67
SPP1
STS
TOP2A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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