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Article

Spectrum and Clinical Impact of Secondary Genetic Alterations in Translocation-Associated Sarcomas.

JCO precision oncology - 1 Oct 2025

Chang Hsin-Yi, Tap William, Slotkin Emily, Wexler Leonard, Reed Damon, Hameed Meera, Vanderbilt Chad, Antonescu Cristina R

Abstract excerpt

PURPOSE: Translocation-associated sarcomas (TASs) encompass a wide spectrum of pathologic entities and clinical behavior. Driven by the oncogenic fusion, TASs typically show a stable genome and a low tumor mutational burden (TMB), with infrequent secondary genetic alterations (SGAs). Although oncogenic/likely oncogenic SGAs have been associated with an aggressive clinical course in certain histotypes, a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41166676
DOI: 10.1200/PO-25-00603
PMCID: PMC13417459

Genes

TP53
TERT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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