Back to search

Article

Integrative multi-omics analysis reveals molecular subtypes and tumor evolution of synovial sarcoma

2022-05-10

Abstract excerpt

Synovial sarcomas (SS) are malignant mesenchymal tumors characterized by the SS18-SSX fusion gene, which drives tumorigenesis by altering the composition of the BAF complex. Secondary genomic alterations that determine variations in tumor phenotype or clinical presentation are largely unknown. Herein, we present transcriptome, targeted DNA-sequencing, and proteomics analysis of 91 synovial sarcomas from 55 patient...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
98224f3e-fe1a-50fc-b806-78b06ed60d34
DOI
10.1101/2022.05.09.490894
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Integrative multi-omics analysis reveals molecular subtypes and tumor evolution of synovial sarcomaDOI 10.1101/2022.05.09.490894
Molecular Profiling Defines Three Subtypes of Synovial SarcomaSemantic proximity
Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas.Semantic proximity
Molecular and epigenetic oncogenesis in synovial sarcoma: implications for cancer biology, diagnosis and treatmentSemantic proximity
Synovial Sarcoma Chromatin Dynamics Reveal a Continuum in SS18:SSX ReprogramingSemantic proximity
Multi‐omics profiling identified two epithelioid sarcoma molecular subtypes with distinct signaling and immune characteristicsSemantic proximity
Identification of potential mutations and genomic alterations in the epithelial and spindle cell components of biphasic synovial sarcomas using a human exome SNP chip.Semantic proximity
Clinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targetsSemantic proximity
Clinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targetsSemantic proximity
The Biology of Synovial Sarcoma: State-of-the-Art and Future PerspectivesSemantic proximity
Opposing immune and genetic forces shape oncogenic programs in synovial sarcomaSemantic proximity
Genetic and Molecular Heterogeneity of Synovial Sarcoma and Associated Challenges in TherapySemantic proximity
Precision Oncology in Sarcomas: Divide and ConquerSemantic proximity
Select a neighboring publication to make it the new centre.