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Article

Association between tacrolimus concentration and genetic polymorphisms of CYP3A5 and ABCB1 during the early stage after liver transplant in an Iranian population.

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation - 1 Feb 2012

Rahsaz Marjan, Azarpira Negar, Nikeghbalian Saman, Aghdaie Mahdokht H, Geramizadeh Bita, Moini Maryam, Banihashemi Mehrzad, Darai Masumeh, Malekpour Zahra, Malekhosseini Seid Ali

Abstract excerpt

OBJECTIVES: Tacrolimus is widely used as an immunosuppressive drug in liver transplant recipients with a narrow therapeutic range and variable individualized pharmacokinetics. Tacrolimus is a substrate of cytochrome P-450 3A enzyme and the drug transporter, P-glycoprotein. MATERIALS AND METHODS: We determined the genotypic frequencies of cytochrome P-4503A5 (rs776746), and ABCB1 (rs1045642), single nucleotide...

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Share to ATP Binding Cassette Transporter, Subfamily B
Share to ATP Binding Cassette Transporter, Subfamily B, Member 1
Share to Cholangitis, Sclerosing
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Share to Liver Transplantation
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Source

Identifiers

PMID: 22309416
DOI: 10.6002/ect.2011.0093

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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