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iNOS-Selective Inhibitors For Cancer Prevention: Promise And Progress

1 Nov 2012

Abstract excerpt

Nitric oxide (NO) is involved in various physiological functions and its role in tumorigenesis has been well studied. A large majority of human and experimental tumors appear to progress owing to NO resulting from iNOS, further stimulated by proinflammatory cytokines. Conversely, in some cases, NO is associated with induction of apoptosis and tumor regression. This dichotomy of NO is largely explained by the...

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PMID: 23190107
DOI: 10.4155/fmc.12.168

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