Article
Nox1 oxidase suppresses influenza a virus-induced lung inflammation and oxidative stress.
PloS one - 1 Jan 2013
Selemidis Stavros, Seow Huei Jiunn, Broughton Brad R S, Vinh Antony, Bozinovski Steven, Sobey Christopher G, Drummond Grant R, Vlahos Ross
Abstract excerpt
Influenza A virus infection is an ongoing clinical problem and thus, there is an urgent need to understand the mechanisms that regulate the lung inflammation in order to unravel novel generic pharmacological strategies. Evidence indicates that the Nox2-containing NADPH oxidase enzyme promotes influenza A virus-induced lung oxidative stress, inflammation and dysfunction via ROS generation. In addition, lung...
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