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Article

NOX1 to NOX2 switch deactivates AMPK and induces invasive phenotype in colon cancer cells through overexpression of MMP-7.

Molecular cancer - 27 Jun 2015

Banskota Suhrid, Regmi Sushil C, Kim Jung-Ae

Abstract excerpt

BACKGROUND: Although matrix metalloproteinase (MMP)-7 expression is correlated with increased metastatic potential in human colon cancer cells, the underlying molecular mechanism of invasive phenotype remains unknown. In the current study, we investigated the regulatory effects of membrane NADPH oxidase (NOX) and AMP activated protein kinase (AMPK) on MMP-7 expression and invasive phenotype change in colon cancer...

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Source

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Identifiers

PMID: 26116564
DOI: 10.1186/s12943-015-0379-0
PMCID: PMC4482031

Genes

NOX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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