Article
Discovery and functional assessment of gene variants in the vascular endothelial growth factor pathway.
Human mutation - 1 Feb 2014
Paré-Brunet Laia, Glubb Dylan, Evans Patrick, Berenguer-Llergo Antoni, Etheridge Amy S, Skol Andrew D, Di Rienzo Anna, Duan Shiwei, Gamazon Eric R, Innocenti Federico
Abstract excerpt
Angiogenesis is a host-mediated mechanism in disease pathophysiology. The vascular endothelial growth factor (VEGF) pathway is a major determinant of angiogenesis, and a comprehensive annotation of the functional variation in this pathway is essential to understand the genetic basis of angiogenesis-related diseases. We assessed the allelic heterogeneity of gene expression, population specificity of cis expression...
Topics
- Black People
- Cell Line, Tumor
- Computational Biology
- Gene Expression
- Genetic Variation
- Genome-Wide Association Study
- Humans
- Linkage Disequilibrium
- Multivariate Analysis
- Neovascularization, Pathologic
- Neovascularization, Physiologic
- Nigeria