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Article

Functional noncoding SNPs in human endothelial cells fine-map vascular trait associations.

Genome research - 1 Mar 2022

Toropainen Anu, Stolze Lindsey K, Örd Tiit, Whalen Michael B, Torrell Paula Martí, Link Verena M, Kaikkonen Minna U, Romanoski Casey E

Abstract excerpt

Functional consequences of genetic variation in the noncoding human genome are difficult to ascertain despite demonstrated associations to common, complex disease traits. To elucidate properties of functional noncoding SNPs with effects in human endothelial cells (ECs), we utilized our previous molecular quantitative trait locus (molQTL) analysis for transcription factor binding, chromatin accessibility, and...

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Identifiers

PMID: 35193936
DOI: 10.1101/gr.276064.121
PMCID: PMC8896458

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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