Article
Six Novel Loci Associated with Circulating VEGF Levels Identified by a Meta-analysis of Genome-Wide Association Studies.
PLoS genetics - 1 Feb 2016
Choi Seung Hoan, Ruggiero Daniela, Sorice Rossella, Song Ci, Nutile Teresa, Vernon Smith Albert, Concas Maria Pina, Traglia Michela, Barbieri Caterina, Ndiaye Ndeye Coumba, Stathopoulou Maria G, Lagou Vasiliki, Maestrale Giovanni Battista, Sala Cinzia, Debette Stephanie, Kovacs Peter, Lind Lars, Lamont John, Fitzgerald Peter, Tönjes Anke, Gudnason Vilmundur, Toniolo Daniela, Pirastu Mario, Bellenguez Celine, Vasan Ramachandran S, Ingelsson Erik, Leutenegger Anne-Louise, Johnson Andrew D, DeStefano Anita L, Visvikis-Siest Sophie, Seshadri Sudha, Ciullo Marina
Abstract excerpt
Vascular endothelial growth factor (VEGF) is an angiogenic and neurotrophic factor, secreted by endothelial cells, known to impact various physiological and disease processes from cancer to cardiovascular disease and to be pharmacologically modifiable. We sought to identify novel loci associated with circulating VEGF levels through a genome-wide association meta-analysis combining data from European-ancestry...
Topics
- Chromosomes, Human
- Gene Expression
- Genetic Loci
- Genome-Wide Association Study
- Humans
- Polymorphism, Single Nucleotide
- Vascular Endothelial Growth Factor A