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Article

Genome-wide association study for endothelial growth factors.

Circulation. Cardiovascular genetics - 1 Apr 2015

Lieb Wolfgang, Chen Ming-Huei, Larson Martin G, Safa Radwan, Teumer Alexander, Baumeister Sebastian E, Lin Honghuang, Smith Holly M, Koch Manja, Lorbeer Roberto, Völker Uwe, Nauck Matthias, Völzke Henry, Wallaschofski Henri, Sawyer Douglas B, Vasan Ramachandran S

Abstract excerpt

BACKGROUND: Endothelial growth factors including angiopoietin-2 (Ang-2), its soluble receptor Tie-2 (sTie-2), and hepatocyte growth factor play important roles in angiogenesis, vascular remodeling, local tumor growth, and metastatic potential of various cancers. Circulating levels of these biomarkers have a heritable component (between 13% and 56%), but the underlying genetic variation influencing these biomarker...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25552591
DOI: 10.1161/CIRCGENETICS.114.000597
PMCID: PMC4406801

Genes

MCPH1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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