Identification of cis- and trans-acting genetic variants explaining up to half the variation in circulating vascular endothelial growth factor levels.

doi:10.1161/CIRCRESAHA.111.243790

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Article

Identification of cis- and trans-acting genetic variants explaining up to half the variation in circulating vascular endothelial growth factor levels.

Circulation research - 19 Aug 2011

Debette Stephanie, Visvikis-Siest Sophie, Chen Ming-Huen, Ndiaye Ndeye-Coumba, Song Ci, Destefano Anita, Safa Radwan, Azimi Nezhad Mohsen, Sawyer Douglas, Marteau Jean-Brice, Xanthakis Vanessa, Siest Gerard, Sullivan Lisa, Pfister Michele, Smith Holly, Choi Seung-Hoan, Lamont John, Lind Lars, Yang Qiong, Fitzgerald Peter, Ingelsson Erik, Vasan Ramachandran S, Seshadri Sudha

Abstract excerpt

RATIONALE: Vascular endothelial growth factor (VEGF) affects angiogenesis, atherosclerosis, and cancer. Although the heritability of circulating VEGF levels is high, little is known about its genetic underpinnings. OBJECTIVE: Our aim was to identify genetic variants associated with circulating VEGF levels, using an unbiased genome-wide approach, and to explore their functional significance with gene expression...

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PMID: 21757650
DOI: 10.1161/CIRCRESAHA.111.243790
PMCID: PMC3193930

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VLDLR
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