Identification of cis- and trans-acting genetic variants explaining up to half the variation in circulating vascular endothelial growth factor levels.

doi:10.1161/CIRCRESAHA.111.243790

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Article

Identification of cis- and trans-acting genetic variants explaining up to half the variation in circulating vascular endothelial growth factor levels.

Circulation research - 19 Aug 2011

Debette Stephanie, Visvikis-Siest Sophie, Chen Ming-Huen, Ndiaye Ndeye-Coumba, Song Ci, Destefano Anita, Safa Radwan, Azimi Nezhad Mohsen, Sawyer Douglas, Marteau Jean-Brice, Xanthakis Vanessa, Siest Gerard, Sullivan Lisa, Pfister Michele, Smith Holly, Choi Seung-Hoan, Lamont John, Lind Lars, Yang Qiong, Fitzgerald Peter, Ingelsson Erik, Vasan Ramachandran S, Seshadri Sudha

Abstract excerpt

RATIONALE: Vascular endothelial growth factor (VEGF) affects angiogenesis, atherosclerosis, and cancer. Although the heritability of circulating VEGF levels is high, little is known about its genetic underpinnings. OBJECTIVE: Our aim was to identify genetic variants associated with circulating VEGF levels, using an unbiased genome-wide approach, and to explore their functional significance with gene expression...

Topics

Adolescent
Adult
Aged
Cohort Studies
Female
Gene Regulatory Networks
Genetic Variation
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Male

Middle Aged

Polymorphism, Single Nucleotide

Prospective Studies

RNA, Messenger

Vascular Endothelial Growth Factor A

Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 21757650
DOI: 10.1161/CIRCRESAHA.111.243790
PMCID: PMC3193930

Genes

VLDLR
ZFPM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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