Whole-genome haplotype reconstruction using proximity-ligation and shotgun sequencing.

Abstract excerpt

Rapid advances in high-throughput sequencing facilitate variant discovery and genotyping, but linking variants into a single haplotype remains challenging. Here we demonstrate HaploSeq, an approach for assembling chromosome-scale haplotypes by exploiting the existence of 'chromosome territories'. We use proximity ligation and sequencing to show that alleles on homologous chromosomes occupy distinct territories,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Algorithms
• Share to Base Sequence
• Share to Chromosome Mapping