Article
On the design of clone-based haplotyping.
Genome biology - 1 Jan 2013
Lo Christine, Liu Rui, Lee Jehyuk, Robasky Kimberly, Byrne Susan, Lucchesi Carolina, Aach John, Church George, Bafna Vineet, Zhang Kun
Abstract excerpt
BACKGROUND: Haplotypes are important for assessing genealogy and disease susceptibility of individual genomes,but are difficult to obtain with routine sequencing approaches. Experimental haplotype reconstruction based on assembling fragments of individual chromosomes is promising, but with variable yields due to incompletely understood parameter choices. RESULTS: We parameterize the clone-based haplotyping...
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