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Article

Whole population, genome-wide mapping of hidden relatedness.

Genome research - 1 Feb 2009

Gusev Alexander, Lowe Jennifer K, Stoffel Markus, Daly Mark J, Altshuler David, Breslow Jan L, Friedman Jeffrey M, Pe'er Itsik

Abstract excerpt

We present GERMLINE, a robust algorithm for identifying segmental sharing indicative of recent common ancestry between pairs of individuals. Unlike methods with comparable objectives, GERMLINE scales linearly with the number of samples, enabling analysis of whole-genome data in large cohorts. Our approach is based on a dictionary of haplotypes that is used to efficiently discover short exact matches between...

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Identifiers

PMID: 18971310
DOI: 10.1101/gr.081398.108
PMCID: PMC2652213

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