MDM2 SNP309 contributes to non-small cell lung cancer survival in Chinese.

doi:10.1002/mc.20727

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Article

MDM2 SNP309 contributes to non-small cell lung cancer survival in Chinese.

Molecular carcinogenesis - 1 Jun 2011

Dong Jing, Ren Binhui, Hu Zhibin, Chen Jiaping, Hu Lingmin, Dai Juncheng, Jin Guangfu, Xu Lin, Shen Hongbing

Abstract excerpt

Murine double minute 2 (MDM2) is a negative regulator of the tumor suppressor gene p53. Single nucleotide polymorphisms in MDM2 and p53 can affect patient's response to chemotherapy as well as overall survival of many cancers. This study aimed to assess the associations between polymorphisms in MDM2 and p53 and survival of non-small cell lung cancer (NSCLC) patients in Chinese. We selected and genotyped both...

Topics

Adenocarcinoma
Antineoplastic Combined Chemotherapy Protocols
Asian People
Carcinoma, Non-Small-Cell Lung
Carcinoma, Squamous Cell
Female
Genotype
Humans
Lung Neoplasms
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Staging

Polymorphism, Single Nucleotide

Prognosis

Proto-Oncogene Proteins c-mdm2

Survival Rate

Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 21268124
DOI: 10.1002/mc.20727

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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