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Article

Insulin pathway related genes and risk of colorectal cancer: INSR promoter polymorphism shows a protective effect.

Endocrine-related cancer - 1 Sept 2007

Pechlivanis Sonali, Pardini Barbara, Bermejo Justo Lorenzo, Wagner Kerstin, Naccarati Alessio, Vodickova Ludmila, Novotny Jan, Hemminki Kari, Vodicka Pavel, Försti Asta

Abstract excerpt

Western lifestyle leading to obesity and type 2 diabetes has been associated with increased risk of colorectal cancer (CRC). Diet and related factors may affect the risk by modifying plasma insulin levels. Thus, the inter-individual variation in insulin signaling may play a plausible role in the development of CRC. We hypothesized that functional polymorphisms in the insulin pathway genes INS, INSR, IGFBPI,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17914103
DOI: 10.1677/ERC-07-0107

Genes

INSR
INS
IRS1
IRS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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