Lack of association between insulin receptor substrate2 rs1805097 polymorphism and the risk of colorectal and breast cancer: a meta-analysis.

doi:10.1371/journal.pone.0086911

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Article

Lack of association between insulin receptor substrate2 rs1805097 polymorphism and the risk of colorectal and breast cancer: a meta-analysis.

PloS one - 1 Jan 2014

Hu Yue, Zhou Min, Zhang Kai, Kong Xiangquan, Hu Xiaoyan, Li Kang, Liu Li

Abstract excerpt

BACKGROUND: Insulin receptor substrate-2 (IRS-2), a signaling adaptor protein, was involved in two cancer-related pathways (the phosphatidylinositol 3'-kinase (PI3K) and the extracellular signal-regulated kinase (ERK) pathways). Several studies have evaluated the association between IRS2 rs1805097 (G>A) polymorphisms and the risk of colorectal and breast cancer. However, the results were inconsistent....

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PMID: 24497996
DOI: 10.1371/journal.pone.0086911
PMCID: PMC3907441

Genes

IRS2

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