Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A B56gamma mutation in lung cancer disrupts the p53-dependent tumor-suppressor function of protein phosphatase 2A.

Oncogene - 8 Jul 2010

Shouse G P, Nobumori Y, Liu X

Abstract excerpt

Earlier studies have shown both p53-dependent and -independent tumor-suppressive functions of B56gamma-specific protein phosphatase 2A (B56gamma-PP2A). In the absence of p53, B56gamma-PP2A can inhibit cell proliferation and cell transformation by an unknown mechanism. In the presence of p53, on DNA damage, a complex including B56gamma-PP2A and p53 is formed, which leads to Thr55 dephosphorylation of p53,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line, Tumor
Share to Cell Proliferation
Share to Lung Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Phosphorylation

Share to Protein Phosphatase 2

Share to Protein Structure, Tertiary

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 20473327
DOI: 10.1038/onc.2010.161
PMCID: PMC2900437

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A B56gamma mutation in lung cancer disrupts the p53-dependent tumor-suppressor function of protein phosphatase 2A.PMID 20473327Read ↗

B56γ tumor-associated mutations provide new mechanisms for B56γ-PP2A tumor suppressor activity.Semantic proximity Read ↗

Suppression of PP2A-B56α drives EMT in EGFR mutant non-small cell lung cancer.Semantic proximity Read ↗

Serine 15 phosphorylation of p53 directs its interaction with B56gamma and the tumor suppressor activity of B56gamma-specific protein phosphatase 2A.Semantic proximity Read ↗

Suppression of PP2A-B56α Drives EMT in EGFR Mutant Non-Small Cell Lung CancerSemantic proximity Read ↗

PP2A:B56{epsilon}, a substrate of caspase-3, regulates p53-dependent and p53-independent apoptosis during development.Semantic proximity Read ↗

Oncoprotein CIP2A is stabilized via interaction with tumor suppressor PP2A/B56.Semantic proximity Read ↗

Human cancer-associated mutations in the Aα subunit of protein phosphatase 2A increase lung cancer incidence in Aα knock-in and knockout mice.Semantic proximity Read ↗

A mutation in protein phosphatase type 2A as a cause of melanoma progression.Semantic proximity Read ↗

A PP2A molecular glue overcomes RAS/MAPK inhibitor resistance in KRAS-mutant non-small cell lung cancer.Semantic proximity Read ↗

p53 controls expression of the DNA deaminase APOBEC3B to limit its potential mutagenic activity in cancer cells.Semantic proximity Read ↗

Requirement for phosphorylation of P53 at Ser312 in suppression of chemical carcinogenesis.Semantic proximity Read ↗

Disruption of serine/threonine protein phosphatase 5 (PP5:PPP5c) in mice reveals a novel role for PP5 in the regulation of ultraviolet light-induced phosphorylation of serine/threonine protein kinase Chk1 (CHEK1).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.