Article
Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress.
Molecular and cellular biology - 1 Apr 2001
Buschmann T, Potapova O, Bar-Shira A, Ivanov V N, Fuchs S Y, Henderson S, Fried V A, Minamoto T, Alarcon-Vargas D, Pincus M R, Gaarde W A, Holbrook N J, Shiloh Y, Ronai Z
Abstract excerpt
The p53 tumor suppressor protein plays a key role in the regulation of stress-mediated growth arrest and apoptosis. Stress-induced phosphorylation of p53 tightly regulates its stability and transcriptional activities. Mass spectrometry analysis of p53 phosphorylated in 293T cells by active Jun NH2-terminal kinase (JNK) identified T81 as the JNK phosphorylation site. JNK phosphorylated p53 at T81 in response to...
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