Article
Association between mutation of the NF2 gene and monosomy 22 in menopausal women with sporadic meningiomas.
BMC medical genetics - 30 Oct 2013
Tabernero MariaDolores, Jara-Acevedo María, Nieto Ana B, Caballero Arancha Rodríguez, Otero Alvaro, Sousa Pablo, Gonçalves Jesús, Domingues Patricia H, Orfao Alberto
Abstract excerpt
BACKGROUND: Meningioma was the first solid tumor shown to contain a recurrent genetic alteration e.g. monosomy 22/del(22q), NF2 being the most relevant gene involved. Although monosomy 22/del(22q) is present in half of all meningiomas, and meningiomas frequently carry NF2 mutations, no study has been reported so far in which both alterations are simultaneously assessed and correlated with the features of the...
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