Article
Familial meningioma is not allelic to neurofibromatosis 2.
Neurology - 1 Oct 1993
Pulst S M, Rouleau G A, Marineau C, Fain P, Sieb J P
Abstract excerpt
Meningiomas frequently lose parts of chromosome 22 (CHR 22), suggesting that a meningioma tumor-suppressor gene is located on CHR 22. Since meningiomas are common in neurofibromatosis 2 (NF2) and the NF2 gene is mapped to CHR 22, the NF2 gene is a candidate for the meningioma gene. To determine whether NF2 and familial meningioma are allelic mutations, we studied a family with multiple meningiomas and ependymomas...
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