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C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice

29 Oct 2013

Abstract excerpt

Accumulating evidence from mice expressing ALS-causing mutations in superoxide dismutase (SOD1) has implicated pathological immune responses in motor neuron degeneration. This includes microglial activation, lymphocyte infiltration, and the induction of C1q, the initiating component of the classic complement system that is the protein-based arm of the innate immune response, in motor neurons of multiple ALS mouse...

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PMID: 24170856
DOI: 10.1073/pnas.1318309110

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