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Article

Dismutase-competent SOD1 mutant accumulation in myelinating Schwann cells is not detrimental to normal or transgenic ALS model mice.

Human molecular genetics - 1 Mar 2010

Turner Bradley J, Ackerley Steven, Davies Kay E, Talbot Kevin

Abstract excerpt

Mutant superoxide dismutase 1 (SOD1) action within non-neuronal cells is implicated in damage to spinal motor neurons in a genetic form of amyotrophic lateral sclerosis (ALS). Central nervous system glial cells such as astrocytes and microglia drive progression in transgenic mutant SOD1 mice, however, the role of myelinating glia remains unclear. Specifically, peripheral myelinating glial cells are likely...

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Identifiers

PMID: 20008901
DOI: 10.1093/hmg/ddp550

Genes

SOD1

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