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Characterization of early pathogenesis in the <scp>SOD1</scp> <sup>G93A</sup> mouse model of <scp>ALS</scp> : part I, background and methods

11 Jun 2013

Abstract excerpt

Charcot first described amyotrophic lateral sclerosis (ALS) in 1869; however, its causes remain largely unknown and effective, long-term treatment strategies are not available. The first mouse model of ALS was developed after the identification of mutations in the superoxide dismutase 1 (SOD1) gene in 1993, and accordingly most of our knowledge of the etiology and pathogenesis of the disease comes from studies...

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PMID: 24381807
DOI: 10.1002/brb3.143

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