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Article

Complement components are upregulated and correlate with disease progression in the TDP-43Q331K mouse model of amyotrophic lateral sclerosis.

Journal of neuroinflammation - 1 Jun 2018

Lee John D, Levin Samantha C, Willis Emily F, Li Rui, Woodruff Trent M, Noakes Peter G

Abstract excerpt

BACKGROUND: Components of the innate immune complement system have been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS) specifically using hSOD1 transgenic animals; however, a comprehensive examination of complement expression in other transgenic ALS models has not been performed. This study therefore aimed to determine the expression of several key complement components and regulators in...

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Source

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Identifiers

PMID: 29859100
DOI: 10.1186/s12974-018-1217-2
PMCID: PMC5984816

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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