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Article

Important scaffold function of the Janus kinase 2 uncovered by a novel mouse model harboring a Jak2 activation-loop mutation.

Blood - 23 Jan 2014

Keil Eric, Finkenstädt David, Wufka Christian, Trilling Mirko, Liebfried Pia, Strobl Birgit, Müller Mathias, Pfeffer Klaus

Abstract excerpt

Janus kinases (Jak) play essential roles in cytokine and growth factor signaling. Conventional gene targeting of Jak2, creating a null allele, leads to a block in definitive erythropoiesis as a result of failing signal transduction at the homomeric erythropoietin receptor (EpoR) and at the heteromeric interferon γ receptor (IFNGR). To investigate the in vivo relevance of the activation loop of Jak2, a...

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Identifiers

PMID: 24169825
DOI: 10.1182/blood-2013-03-492157

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Important scaffold function of the Janus kinase 2 uncovered by a novel mouse model harboring a Jak2 activation-loop mutation.PMID 24169825Read ↗

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