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Article

Jak2: normal function and role in hematopoietic disorders.

Current opinion in genetics & development - 1 Feb 2007

Ihle James N, Gilliland D Gary

Abstract excerpt

Janus kinase 2 (Jak2) associates with cytokine receptors and is essential for signal transduction by mediating tyrosine phosphorylation. Kinase activity is regulated by a series of interactions beginning with the requirement to bind to specific domains in receptors, suppression of activation by the pseudokinase domain, and the requirement for phosphorylation within the activation loop. Recent studies have...

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Share to Gene Expression Regulation, Neoplastic
Share to Hematologic Neoplasms
Share to Janus Kinase 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myeloproliferative Disorders

Share to Phosphorylation

Share to Receptors, Cytokine

Share to Translocation, Genetic

Share to Tyrosine

Source

Identifiers

PMID: 17208428
DOI: 10.1016/j.gde.2006.12.009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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