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Article

Two domains of the erythropoietin receptor are sufficient for Jak2 binding/activation and function.

Molecular and cellular biology - 1 Nov 2006

Pelletier Stéphane, Gingras Sébastien, Funakoshi-Tago Megumi, Howell Sherié, Ihle James N

Abstract excerpt

Biochemical and genetic studies have shown that Jak2 is an essential component of EpoR signal transduction which is required for normal erythropoiesis. However, whether Jak2 is the sole direct mediator of EpoR signal transduction remains controversial. To address this issue, we have used an extensive and systematic mutational analysis across the EpoR cytoplasmic tail and transmembrane domain with the goal of...

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Identifiers

PMID: 16982687
DOI: 10.1128/MCB.01035-06
PMCID: PMC1636781

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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