Article
Jak2 is essential for signaling through a variety of cytokine receptors.
Cell - 1 May 1998
Parganas E, Wang D, Stravopodis D, Topham D J, Marine J C, Teglund S, Vanin E F, Bodner S, Colamonici O R, van Deursen J M, Grosveld G, Ihle J N
Abstract excerpt
A variety of cytokines activate receptor-associated members of the Janus family of protein tyrosine kinases (Jaks). To assess the role of Jak2, we have derived Jak2-deficient mice. The mutation causes an embryonic lethality due to the absence of definitive erythropoiesis. Fetal liver myeloid progenitors, although present based on the expression of lineage specific markers, fail to respond to erythropoietin,...
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