JAKs in pathology: role of Janus kinases in hematopoietic malignancies and immunodeficiencies.

doi:10.1016/j.semcdb.2008.07.002

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Article

JAKs in pathology: role of Janus kinases in hematopoietic malignancies and immunodeficiencies.

Seminars in cell & developmental biology - 1 Aug 2008

Vainchenker William, Dusa Alexandra, Constantinescu Stefan N

Abstract excerpt

The four mammalian Janus kinase (JAK) family members, JAK1, JAK2, JAK3 and TYK2, are non-receptor protein tyrosine kinases (PTKs) that are crucial for cytokine receptor signaling in blood formation and immune responses. Mutations and translocations in the JAK genes leading to constitutively active JAK proteins are associated with a variety of hematopoietic malignancies, including the myeloproliferative disorders...

Topics

Animals
Enzyme Activation
Hematologic Neoplasms
Humans
Immunologic Deficiency Syndromes
Isoenzymes
Janus Kinases
Mutation
Receptors, Cytokine
Recombinant Fusion Proteins
Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 18682296
DOI: 10.1016/j.semcdb.2008.07.002

Genes

JAK2
JAK1
JAK3
TYK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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