Article
A functional Jak2 tyrosine kinase domain is essential for mouse development.
Experimental cell research - 10 Sept 2006
Frenzel Kristen, Wallace Tiffany A, McDoom Issam, Xiao Hong D, Capecchi Mario R, Bernstein Kenneth E, Sayeski Peter P
Abstract excerpt
Jak2 is a member of the Janus family of tyrosine kinases and is involved in cytokine signaling. As a part of a study to determine biological functions of Jak2, we used molecular modeling to identify W1038 as a residue that is critical for tyrosine kinase function. Mutation of W1038, in tandem with E1046, generates a dominant-negative form of the Jak2 protein. Mice that were engineered to express two copies of...
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