Article
Activating JAK2 mutants reveal cytokine receptor coupling differences that impact outcomes in myeloproliferative neoplasm.
Leukemia - 1 Oct 2017
Yao H, Ma Y, Hong Z, Zhao L, Monaghan S A, Hu M-C, Huang L J
Abstract excerpt
Janus tyrosine kinase 2 (JAK2) mediates downstream signaling of cytokine receptors in all hematological lineages, yet constitutively active JAK2 mutants are able to drive selective expansion of particular lineage(s) in myeloproliferative neoplasm (MPN). The molecular basis of lineage specificity is unclear. Here, we show that three activating JAK2 mutants with similar kinase activities in vitro elicit distinctive...
Topics
- Animals
- Cell Division
- Cell Line
- Cell Lineage
- Enzyme Activation
- Erythropoiesis
- Exons
- Genes, Reporter
- Hematopoietic Stem Cells
- Humans
- Janus Kinase 2
- Mice
- Mice, Inbred BALB C
- Mutation, Missense