Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor.

Molecular cell - 1 Dec 2001

Huang L J, Constantinescu S N, Lodish H F

Abstract excerpt

We show that Janus kinase 2 (JAK2), and more specifically just its intact N-terminal domain, binds to the erythropoietin receptor (EpoR) in the endoplasmic reticulum and promotes its cell surface expression. This interaction is specific as JAK1 has no effect. Residues 32 to 58 of the JAK2 JH7 domain are required for EpoR surface expression. Alanine scanning mutagenesis of the EpoR membrane proximal region reveals...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endoplasmic Reticulum
Share to Golgi Apparatus
Share to Janus Kinase 1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Janus Kinase 2

Share to Protein Processing, Post-Translational

Share to Protein-Tyrosine Kinases

Share to Receptors, Erythropoietin

Share to Receptors, Prolactin

Source

Identifiers

PMID: 11779507
DOI: 10.1016/s1097-2765(01)00401-4

Genes

JAK2
JAK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor.PMID 11779507Read ↗

Two domains of the erythropoietin receptor are sufficient for Jak2 binding/activation and function.Semantic proximity Read ↗

Important scaffold function of the Janus kinase 2 uncovered by a novel mouse model harboring a Jak2 activation-loop mutation.Semantic proximity Read ↗

Molecular basis of JAK2 activation in erythropoietin receptor and pathogenic JAK2 signaling.Semantic proximity Read ↗

Receptor-mediated dimerization of JAK2 FERM domains is required for JAK2 activation.Semantic proximity Read ↗

The erythropoietin receptor: biogenesis, dimerization, and intracellular signal transduction.Semantic proximity Read ↗

Structural requirements of the extracellular to transmembrane domain junction for erythropoietin receptor function.Semantic proximity Read ↗

Generation of a conditional knockout allele for the <i>Janus kinase 2</i> (<i>Jak2</i>) gene in miceSemantic proximity Read ↗

Erythropoietin induces activation of Stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response.Semantic proximity Read ↗

Amino acid residues 268-276 of the erythropoietin receptor contain an endocytosis motif and are required for erythropoietin-mediated proliferation.Semantic proximity Read ↗

Janus kinase 2 determinants for growth hormone receptor association, surface assembly, and signaling.Semantic proximity Read ↗

Insertion of an NPVY sequence into the cytosolic domain of the erythropoietin receptor selectively affects erythropoietin-mediated signalling and function.Semantic proximity Read ↗

Negative regulation of Jak2 by its auto-phosphorylation at tyrosine 913 via the Epo signaling pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.