The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor.

doi:10.1016/s1097-2765(01)00401-4

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Article

The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor.

Molecular cell - 1 Dec 2001

Huang L J, Constantinescu S N, Lodish H F

Abstract excerpt

We show that Janus kinase 2 (JAK2), and more specifically just its intact N-terminal domain, binds to the erythropoietin receptor (EpoR) in the endoplasmic reticulum and promotes its cell surface expression. This interaction is specific as JAK1 has no effect. Residues 32 to 58 of the JAK2 JH7 domain are required for EpoR surface expression. Alanine scanning mutagenesis of the EpoR membrane proximal region reveals...

Topics

Amino Acid Sequence
Animals
Binding Sites
Cell Line
Cell Membrane
Endoplasmic Reticulum
Enzyme Activation
Fibroblasts
Gene Deletion
Golgi Apparatus
Janus Kinase 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Janus Kinase 2

Mice

Molecular Sequence Data

Mutation

Protein Binding

Protein Folding

Protein Processing, Post-Translational

Source

Open in PubMed

Identifiers

PMID: 11779507
DOI: 10.1016/s1097-2765(01)00401-4

Genes

JAK2
JAK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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