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Article

Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis.

Cell - 1 May 1998

Neubauer H, Cumano A, Müller M, Wu H, Huffstadt U, Pfeffer K

Abstract excerpt

Janus kinases (Jaks) play an important role in signal transduction via cytokine and growth factor receptors. A targeted inactivation of Jak2 was performed. Jak2-/- embryos are anemic and die around day 12.5 postcoitum. Primitive erythrocytes are found, but definitive erythropoiesis is absent. Compared to erythropoietin receptor-deficient mice, the phenotype of Jak2 deficiency is more severe. Fetal liver BFU-E and...

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PMID: 9590174
DOI: 10.1016/s0092-8674(00)81168-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis.PMID 9590174Read ↗

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