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Article

A-to-I editing of protein coding and noncoding RNAs

18 Sept 2012

Abstract excerpt

Adenosine deaminase acting on RNA (ADAR) catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) substrates. Inosine pairs preferentially with cytidine, as opposed to uridine; therefore, ADAR editing alters the sequence and base pairing properties of both protein-coding and non-coding RNA. Editing can directly alter the sequence of protein-coding transcripts and modify...

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PMID: 22988838
DOI: 10.3109/10409238.2012.714350

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