Article
Adenosine-to-inosine RNA editing shapes transcriptome diversity in primates.
Proceedings of the National Academy of Sciences of the United States of America - 6 Jul 2010
Paz-Yaacov Nurit, Levanon Erez Y, Nevo Eviatar, Kinar Yaron, Harmelin Alon, Jacob-Hirsch Jasmine, Amariglio Ninette, Eisenberg Eli, Rechavi Gideon
Abstract excerpt
Human and chimpanzee genomes are almost identical, yet humans express higher brain capabilities. Deciphering the basis for this superiority is a long sought-after challenge. Adenosine-to-inosine (A-to-I) RNA editing is a widespread modification of the transcriptome. The editing level in humans is significantly higher compared with nonprimates, due to exceptional editing within the primate-specific Alu sequences,...
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