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Transcript Diversification in the Nervous System: A to I RNA Editing in CNS Function and Disease Development

1 Jan 2012

Abstract excerpt

RNA editing by adenosine deaminases that act on RNA converts adenosines to inosines in coding and non-coding regions of mRNAs. Inosines are interpreted as guanosines and hence, this type of editing can change codons, alter splice patterns, or influence the fate of an RNA. A to I editing is most abundant in the central nervous system (CNS). Here, targets for this type of nucleotide modification frequently encode...

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PMID: 22787438
DOI: 10.3389/fnins.2012.00099

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