Article
Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients.
Journal of lipid research - 1 Dec 2012
Janssens Michelle, van Smeden Jeroen, Gooris Gert S, Bras Wim, Portale Guiseppe, Caspers Peter J, Vreeken Rob J, Hankemeier Thomas, Kezic Sanja, Wolterbeek Ron, Lavrijsen Adriana P, Bouwstra Joke A
Abstract excerpt
A hallmark of atopic eczema (AE) is skin barrier dysfunction. Lipids in the stratum corneum (SC), primarily ceramides, fatty acids, and cholesterol, are crucial for the barrier function, but their role in relation to AE is indistinct. Filaggrin is an epithelial barrier protein with a central role in the pathogenesis of AE. Nevertheless, the precise causes of AE-associated barrier dysfunction are largely unknown....
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