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Article

Androgen deprivation upregulates SPINK1 expression and potentiates cellular plasticity in prostate cancer

20 Jan 2020

Abstract excerpt

Emergence of an aggressive androgen receptor (AR)-independent neuroendocrine prostate cancer (NEPC) after androgen-deprivation therapy (ADT) is well-known. Nevertheless, the majority of advanced-stage prostate cancer patients, including those with SPINK1-positive subtype, are treated with AR-antagonists. Here, we show AR and its corepressor, REST, function as transcriptional-repressors of SPINK1, and...

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PMID: 31959826
DOI: 10.1038/s41467-019-14184-0

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