Article

A novel REST-regulated lncRNA PCAT-NE1 induces neuroendocrine differentiation in castration-resistant prostate cancer

2022-06-22

Abstract excerpt

<h4>Background: </h4> Lineage plasticity is recognized as a treatment-induced resistance mechanism in prostate cancer (PCa) and contributes to the development of neuroendocrine prostate cancer (NEPC), a lethal variant of castration-resistant prostate cancer (CRPC), that is increasing in the era of second-generation anti-hormonal therapy. At present, there are no effective treatments for NEPC. <h4>Conclusions: </h4...

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Literature Corpus work: 7d901f26-8be8-5fbe-a79a-79e5934e8d1b
DOI: 10.21203/rs.3.rs-1761199/v1

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