Back to search

Article

Androgen deprivation induces neuroendocrine phenotypes in prostate cancer cells through CREB1/EZH2-mediated downregulation of REST

2023-10-04

Abstract excerpt

<title>Abstract</title> <p>Although effective initially, prolonged androgen deprivation therapy (ADT) promotes neuroendocrine differentiation (NED) and prostate cancer (PCa) progression. It is incompletely understood how ADT transcriptionally induces NE genes in PCa cells. CREB1 and REST are known to positively and negatively regulate neuronal gene expression in the brain, respectively. No direct link between the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b84527a8-5130-5eec-8637-a83a3d59a6d8
DOI
10.21203/rs.3.rs-3270539/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Androgen deprivation induces neuroendocrine phenotypes in prostate cancer cells through CREB1/EZH2-mediated downregulation of RESTDOI 10.21203/rs.3.rs-3270539/v1
A novel REST-regulated lncRNA PCAT-NE1 induces neuroendocrine differentiation in castration-resistant prostate cancerSemantic proximity
REST mediates androgen receptor actions on gene repression and predicts early recurrence of prostate cancerSemantic proximity
Defined cellular reprogramming of androgen receptor-active prostate cancer to neuroendocrine prostate cancerSemantic proximity
Implications of PI3K/AKT inhibition on REST protein stability and neuroendocrine phenotype acquisition in prostate cancer cellsSemantic proximity
REST is a crucial regulator for acquiring EMT-like and stemness phenotypes in hormone-refractory prostate cancer.Semantic proximity
Androgen deprivation upregulates SPINK1 expression and potentiates cellular plasticity in prostate cancerSemantic proximity
Androgen deprivation promotes neuroendocrine differentiation and angiogenesis through CREB-EZH2-TSP1 pathway in prostate cancersSemantic proximity
RNA Splicing Factors SRRM3 and SRRM4 Distinguish Molecular Phenotypes of Castration-Resistant Neuroendocrine Prostate CancerSemantic proximity
LncRNA-p21 alters the antiandrogen enzalutamide-induced prostate cancer neuroendocrine differentiation via modulating the EZH2/STAT3 signalingSemantic proximity
Role of MicroRNAs in Neuroendocrine Prostate CancerSemantic proximity
Polycomb-mediated silencing in neuroendocrine prostate cancerSemantic proximity
Reduction of two histone marks, H3k9me3 and H3k27me3 by epidrug induces neuroendocrine differentiation in prostate cancerSemantic proximity
Select a neighboring publication to make it the new centre.